致し方ない

What does 致し方ない mean in English?

1. there's no (other) way(exp, adj-i)
2. cannot be helped; unavoidable; inevitable; (there's) nothing one can do; having no choice(exp, adj-i)
3. it's no use (doing); pointless; useless; no good; insufficient; not enough(exp, adj-i)
4. hopeless (person); annoying; troublesome; awful(exp, adj-i)
5. cannot stand it; unbearable; cannot help (doing, feeling); dying (to do)(exp, adj-i)